Endocrine Abstracts

Thyroid-stimulating hormone (TSH, thyrotropin) is an activator of the TSH receptor (TSHR) in the hypothalamic-pituitary-thyroid axis leading to biosynthesis and secretion of thyroid hormones. We have developed an orally available small molecule, allosteric TSHR agonist, E2, for follow up diagnosis of patients with thyroid cancer. This ligand could replace recombinant human TSH (rhTSH, Thyrogen) which is currently used in the clinic. In a mouse model, oral administration of E2 ...